Characterization of osteoarthritis in patients with diabetes

Investigation of the clinical and pathogenesis aspects of osteoarthritis in combinations with diabetes mellitus type 2. Were studied 80 patients with osteoarthritis, 52 of them has a comorbidity disease such as diabetes mellitus type 2. Were investigated the clinical and radiological signs of disease severity, the levels of cytokines, NO, leptin, and CRP in serum, and levels of blood glucose, and levels of glycated hemoglobin, and SSE. Were found significant differences in body weight, data of ESR, features functional status of the joints and the quality of life in patients with osteoarthritis in combination with type 2 diabetes compared with those without the metabolic disturbance. Moreover, in patients with osteoarthritis of comorbidity for T2DM was established elevated level of IL-6, IL-18, NO and leptin in serum. Were determined differences in the features of the clinical symptoms of osteoarthritis in patients with type 2 diabetes based on blood glucose level, and data of glycated hemoglobin. Were obtained some correlations between of the levels of cytokines in the blood serum with the parameters of the functional status of the joints, and with the quality of life in patients with osteoarthritis in combination with type 2 diabetes. Osteoarthritis in combinations with diabetes mellitus type 2 characterized by a more pronounced severity of clinical symptoms, and functions impairment. Abbreviations: OA: osteoarthritis; T2DM: diabetes mellitus type 2; IL-1β: interleukin 1 beta; IL-6: interleukin 6; IL-10: interleukin 10; IL-18: interleukin 18; TNF-α: tumor necrosis factor alpha; NO: nitrite oxide; CRP: C-reactive protein; SSE: subsidence of erythrocytes; BWI: body weight index